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Article

Single amino acid mutation of Fc gamma receptor is associated with the development of heparin-induced thrombocytopenia.

British journal of haematology - 1 Nov 1995

Burgess J K, Lindeman R, Chesterman C N, Chong B H

Abstract excerpt

Heparin-induced thrombocytopenia (HIT) is mediated by a heparin-dependent antibody/platelet factor 4/heparin complex binding to platelets via the Fc gamma receptor (type IIA). A single base polymorphism at position 131 of Fc gamma RIIA changes the native arginine to histidine. In the presence of murine monoclonal IgG1 the former phenotype (Fc gamma RIIAArg131) is functionally characterized by strong platelet...

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Source

Identifiers

PMID: 8555090
DOI: 10.1111/j.1365-2141.1995.tb05383.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single amino acid mutation of Fc gamma receptor is associated with the development of heparin-induced thrombocytopenia.PMID 8555090Read ↗

The homozygous FcgammaRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes.Semantic proximity Read ↗

On the role of platelet Fc gamma RIIa phenotype in heparin-induced thrombocytopenia.Semantic proximity Read ↗

Heparin-induced thrombocytopenia: new insights into the impact of the FcgammaRIIa-R-H131 polymorphism.Semantic proximity Read ↗

Increased risk of thrombosis in FcγRIIA 131RR patients with HIT due to defective control of platelet activation by plasma IgG2.Semantic proximity Read ↗

Polymorphism of the Fcγ Receptor II as a Possible Predisposing Factor for Heparin-Induced Thrombocytopenia.Semantic proximity Read ↗

Importance of the FcgammaRIIa-Arg/His-131 polymorphism in heparin-induced thrombocytopenia diagnosis.Semantic proximity Read ↗

Heparin-induced thrombocytopenia: the role of platelets genetic polymorphisms.Semantic proximity Read ↗

A naturally occurring mutation in Fc gamma RIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor.Semantic proximity Read ↗

Single Nucleotide Polymorphisms of the High Affinity IgG Receptor FcγRI Reduce Immune Complex Binding and Downstream Effector Functions.Semantic proximity Read ↗

Differential binding to human FcgammaRIIa and FcgammaRIIb receptors by human IgG wildtype and mutant antibodies.Semantic proximity Read ↗

Polymorphisms of protein tyrosine phosphatase CD148 influence FcγRIIA-dependent platelet activation and the risk of heparin-induced thrombocytopenia.Semantic proximity Read ↗

Platelet FcgammaRIIA His131Arg polymorphism and platelet function: antibodies to platelet-bound fibrinogen induce platelet activation.Semantic proximity Read ↗

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