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Article

Single amino acid mutation of Fc gamma receptor is associated with the development of heparin-induced thrombocytopenia.

British journal of haematology - 1 Nov 1995

Burgess J K, Lindeman R, Chesterman C N, Chong B H

Abstract excerpt

Heparin-induced thrombocytopenia (HIT) is mediated by a heparin-dependent antibody/platelet factor 4/heparin complex binding to platelets via the Fc gamma receptor (type IIA). A single base polymorphism at position 131 of Fc gamma RIIA changes the native arginine to histidine. In the presence of...

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Identifiers

PMID: 8555090
DOI: 10.1111/j.1365-2141.1995.tb05383.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8555090-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Single amino acid mutation of Fc gamma receptor is associated with the development of heparin-induced thrombocytopenia.PMID 8555090Read ↗

The homozygous FcgammaRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes.Semantic proximity Read ↗

On the role of platelet Fc gamma RIIa phenotype in heparin-induced thrombocytopenia.Semantic proximity Read ↗

Heparin-induced thrombocytopenia: new insights into the impact of the FcgammaRIIa-R-H131 polymorphism.Semantic proximity Read ↗

Increased risk of thrombosis in FcγRIIA 131RR patients with HIT due to defective control of platelet activation by plasma IgG2.Semantic proximity Read ↗

Polymorphism of the Fcγ Receptor II as a Possible Predisposing Factor for Heparin-Induced Thrombocytopenia.Semantic proximity Read ↗

Importance of the FcgammaRIIa-Arg/His-131 polymorphism in heparin-induced thrombocytopenia diagnosis.Semantic proximity Read ↗

Heparin-induced thrombocytopenia: the role of platelets genetic polymorphisms.Semantic proximity Read ↗

A naturally occurring mutation in Fc gamma RIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor.Semantic proximity Read ↗

Single Nucleotide Polymorphisms of the High Affinity IgG Receptor FcγRI Reduce Immune Complex Binding and Downstream Effector Functions.Semantic proximity Read ↗

Differential binding to human FcgammaRIIa and FcgammaRIIb receptors by human IgG wildtype and mutant antibodies.Semantic proximity Read ↗

Polymorphisms of protein tyrosine phosphatase CD148 influence FcγRIIA-dependent platelet activation and the risk of heparin-induced thrombocytopenia.Semantic proximity Read ↗

Platelet FcgammaRIIA His131Arg polymorphism and platelet function: antibodies to platelet-bound fibrinogen induce platelet activation.Semantic proximity Read ↗

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