Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

doi:10.1074/jbc.M113.502203

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Article

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

The Journal of biological chemistry - 11 Oct 2013

Alzayady Kamil J, Wagner Larry E, Chandrasekhar Rahul, Monteagudo Alina, Godiska Ronald, Tall Gregory G, Joseph Suresh K, Yule David I

Abstract excerpt

Vertebrate genomes code for three subtypes of inositol 1,4,5-trisphosphate (IP3) receptors (IP3R1, -2, and -3). Individual IP3R monomers are assembled to form homo- and heterotetrameric channels that mediate Ca(2+) release from intracellular stores. IP3R subtypes are regulated differentially by IP3, Ca(2+), ATP, and various other cellular factors and events. IP3R subtypes are seldom expressed in isolation in...

Topics

Animals
Calcium
Cell Line
Cell Membrane
Cytosol
Humans
Immunoblotting
Inositol 1,4,5-Trisphosphate Receptors
Ion Channel Gating
Membrane Potentials
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Patch-Clamp Techniques

Protein Isoforms

Protein Multimerization

Protein Subunits

Tissue Extracts

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Identifiers

PMID: 23955339
DOI: 10.1074/jbc.M113.502203
PMCID: PMC3795275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23955339-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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