Article
Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function.
The Journal of biological chemistry - 25 Dec 2020
Terry Lara E, Alzayady Kamil J, Wahl Amanda M, Malik Sundeep, Yule David I
Abstract excerpt
The inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which form tetrameric channels, play pivotal roles in regulating the spatiotemporal patterns of intracellular calcium signals. Mutations in IP3Rs have been increasingly associated with many debilitating human diseases such as ataxia, Gille...
Topics
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Calcium
- Calcium Signaling
- Chickens
- Inositol 1,4,5-Trisphosphate
- Inositol 1,4,5-Trisphosphate Receptors
- Ion Channel Gating
- Mutation
- Protein Multimerization
- Sequence Homology