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Article

Location of the permeation pathway in the recombinant type 1 inositol 1,4,5-trisphosphate receptor.

The Journal of general physiology - 1 Aug 1999

Ramos-Franco J, Galvan D, Mignery G A, Fill M

Abstract excerpt

The inositol 1,4,5-trisphosphate receptor (InsP(3)R) forms ligand-regulated intracellular Ca(2+) release channels in the endoplasmic reticulum of all mammalian cells. The InsP(3)R has been suggested to have six transmembrane regions (TMRs) near its carboxyl terminus. A TMR-deletion mutation strategy was applied to define the location of the InsP(3)R pore. Mutant InsP(3)Rs were expressed in COS-1 cells and single...

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Identifiers

PMID: 10436000
DOI: 10.1085/jgp.114.2.243
PMCID: PMC2230642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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