Article
Location of the permeation pathway in the recombinant type 1 inositol 1,4,5-trisphosphate receptor.
The Journal of general physiology - 1 Aug 1999
Ramos-Franco J, Galvan D, Mignery G A, Fill M
Abstract excerpt
The inositol 1,4,5-trisphosphate receptor (InsP(3)R) forms ligand-regulated intracellular Ca(2+) release channels in the endoplasmic reticulum of all mammalian cells. The InsP(3)R has been suggested to have six transmembrane regions (TMRs) near its carboxyl terminus. A TMR-deletion mutation strat...
Topics
- Amino Acid Sequence
- Animals
- COS Cells
- Calcium Channels
- Centrifugation, Density Gradient
- Cesium
- Gene Deletion
- Inositol 1,4,5-Trisphosphate Receptors
- Ligands
- Lipid Bilayers
- Molecular Sequence Data
- Mutation
- Permeability
- Plasmids
- Receptors, Cytoplasmic and Nuclear
- Recombinant Proteins