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Article

Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.

The Journal of biological chemistry - 12 Nov 2010

Chan Jenny, Yamazaki Haruka, Ishiyama Noboru, Seo Min-Duk, Mal Tapas K, Michikawa Takayuki, Mikoshiba Katsuhiko, Ikura Mitsuhiko

Abstract excerpt

The three isoforms of the inositol 1,4,5-trisphosphate receptor (IP(3)R) exhibit distinct IP(3) sensitivities and cooperativities in calcium (Ca(2+)) channel function. The determinants underlying this isoform-specific channel gating mechanism have been localized to the N-terminal suppressor region of IP(3)R. We determined the 1.9 Å crystal structure of the suppressor domain from type 3 IP(3)R (IP(3)R3(SUP), amino...

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Identifiers

PMID: 20843799
DOI: 10.1074/jbc.M110.140160
PMCID: PMC2975231

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