Article
Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.
The Journal of biological chemistry - 12 Nov 2010
Chan Jenny, Yamazaki Haruka, Ishiyama Noboru, Seo Min-Duk, Mal Tapas K, Michikawa Takayuki, Mikoshiba Katsuhiko, Ikura Mitsuhiko
Abstract excerpt
The three isoforms of the inositol 1,4,5-trisphosphate receptor (IP(3)R) exhibit distinct IP(3) sensitivities and cooperativities in calcium (Ca(2+)) channel function. The determinants underlying this isoform-specific channel gating mechanism have been localized to the N-terminal suppressor regio...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Crystallography, X-Ray
- Inositol 1,4,5-Trisphosphate
- Inositol 1,4,5-Trisphosphate Receptors
- Ion Channel Gating
- Ligands
- Magnetic Resonance Spectroscopy
- Mice
- Models, Molecular
- Molecular Sequence Data
- Mutation