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Article

The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.

The Journal of biological chemistry - 15 Jul 2005

Kim Sanghyeon, Ahn Taeho, Park Chankyu

Abstract excerpt

Inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular Ca2+ channel involved in various cellular signaling. Type 3 IP3R (IP3R3) retains ligand-gated Ca2+ channel properties differing from other subtypes in terms of IP3-binding affinity and regulation of its channel activity by effector molecules. In this study, we found the natural Pro335 --> Leu polymorphism of mouse IP3R3 between BALB/c and C57BL/6J....

Topics

Alleles
Amino Acid Sequence
Animals
Blotting, Western
Calcium
Calcium Channels
Circular Dichroism
DNA, Complementary
Dose-Response Relationship, Drug
Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fluorescent Dyes

Genetic Vectors

Glutathione Transferase

Histidine

Immunoprecipitation

Indoles

Inositol 1,4,5-Trisphosphate Receptors

Intestinal Mucosa

Source

Identifiers

PMID: 15890645
DOI: 10.1074/jbc.M501777200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15890645-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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