Article
Assessment of the role of the inositol 1,4,5-trisphosphate receptor in the activation of transient receptor potential channels and store-operated Ca2+ entry channels.
The Journal of biological chemistry - 1 Jun 2001
Ma H T, Venkatachalam K, Li H S, Montell C, Kurosaki T, Patterson R L, Gill D L
Abstract excerpt
The mechanism for coupling between Ca(2+) stores and store-operated channels (SOCs) is an important but unresolved question. Although SOCs have not been molecularly identified, transient receptor potential (TRP) channels share a number of operational parameters with SOCs. The question of whether activation of SOCs and TRP channels is mediated by the inositol 1,4,5-trisphosphate receptor (InsP(3)R) was examined...
Topics
- Adenosine
- Animals
- Animals, Genetically Modified
- Boron Compounds
- Calcium
- Calcium Channel Agonists
- Calcium Channels
- Carbachol
- Cell Line
- Chickens
- Dose-Response Relationship, Drug