APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42.

doi:10.1212/01.wnl.0000128088.08695.05

Article

APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42.

Neurology - 8 Jun 2004

Prince J A, Zetterberg H, Andreasen N, Marcusson J, Blennow K

Abstract excerpt

The epsilon4 allele of APOE is a risk factor for Alzheimer disease (AD). By analysis of a large cohort of AD patients (n = 563) and control subjects (n = 118), it is shown that the epsilon4 allele is strongly associated with reduced CSF levels of beta-amyloid (1-42) (Abeta42) in both AD (p < 10(-9)) and control (p = 0.0012) populations. As no associations of APOE variants with other indexes of AD severity were...

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APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42.

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APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42.

Abstract excerpt

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