Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease.

doi:10.1007/BF00225071

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Article

Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease.

Human genetics - 1 Jan 1995

Lehtimäki T, Pirttilä T, Mehta P D, Wisniewski H M, Frey H, Nikkari T

Abstract excerpt

The apoE phenotype of 83 patients with probable Alzheimer's disease (AD) and of 164 non-demented controls was determined by isoelectric focusing and Western blotting. The proportion of the epsilon 4 allele was 0.548 in AD and 0.202 in controls (P < 0.0001). The effect was seen in both early-onset...

Topics

Age of Onset
Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Female
Finland
Gene Frequency
Humans
Male
Middle Aged
Phenotype
Polymorphism, Genetic
Risk Factors

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