The apolipoprotein E allele epsilon 4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease.

doi:10.1212/wnl.44.10.1950

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Article

The apolipoprotein E allele epsilon 4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease.

Neurology - 1 Oct 1994

Galasko D, Saitoh T, Xia Y, Thal L J, Katzman R, Hill L R, Hansen L

Abstract excerpt

We determined apolipoprotein E (ApoE) genotypes in 122 autopsied demented patients. The frequency of the ApoE epsilon 4 allele was 39.6% in Alzheimer's disease (AD), 29.0% in the Lewy body variant of AD (LBV), and 6.25% in diffuse Lewy body disease. For AD and LBV patients, the epsilon 4 frequenc...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoproteins E
Female
Gene Frequency
Genotype
Humans
Lewy Bodies
Male
Risk Factors

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