Article
Preclinical cognitive decline in late middle-aged asymptomatic apolipoprotein E-e4/4 homozygotes: a replication study.
Journal of the neurological sciences - 15 Aug 2001
Caselli R J, Osborne D, Reiman E M, Hentz J G, Barbieri C J, Saunders A M, Hardy J, Graff-Radford N R, Hall G R, Alexander G E
Abstract excerpt
In a previous cross-sectional study of 100 asymptomatic individuals aged 49-69, we reported age-related decline in immediate and delayed memory that was steeper in apolipoprotein E (apoE)-e4/4 homozygotes than in members of other genetic subgroups. These findings were preliminarily based upon the statistical problem of multiple comparisons. We therefore sought to replicate these findings in a new cohort. From...
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