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Article

Influence of apolipoprotein E varepsilon4 on rates of cognitive and functional decline in mild cognitive impairment.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2010

Whitehair Danielle C, Sherzai Abdullah, Emond Jennifer, Raman Rema, Aisen Paul S, Petersen Ronald C, Fleisher Adam S

Abstract excerpt

BACKGROUND: Apolipoprotein E varepsilon4 (APOE varepsilon4) allele carrier status has been well established as a risk factor for developing Alzheimer's disease. However, the specific influence of APOE varepsilon4 allele status on cognitive and functional rates of decline in mild cognitive impairment (MCI) is poorly understood. We examine the prospective association of APOE varepsilon4 allele status on measures of...

Topics

Aged
Aged, 80 and over
Apolipoprotein E4
Cholinesterase Inhibitors
Cognition Disorders
Disease Progression
Donepezil
Female
Follow-Up Studies
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Indans

Male

Middle Aged

Neuropsychological Tests

Piperidines

Psychiatric Status Rating Scales

Randomized Controlled Trials as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 20813342
DOI: 10.1016/j.jalz.2009.12.003
PMCID: PMC2943876

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20813342-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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