Article
Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment.
Archives of neurology - 1 Sept 2007
Caselli Richard J, Reiman Eric M, Locke Dona E C, Hutton Michael L, Hentz Joseph G, Hoffman-Snyder Charlene, Woodruff Bryan K, Alexander Gene E, Osborne David
Abstract excerpt
BACKGROUND: Memory declines more rapidly with age in apolipoprotein E (APOE) epsilon4 carriers than in APOE epsilon4 noncarriers, and APOE epsilon4 homozygotes' cognitive performances correlate with stressors. These changes could represent presymptomatic disease in some, despite their youth. OBJECTIVE: To show that presymptomatic APOE epsilon4 homozygotes experience greater psychometric decline at a younger age...
Topics
- Aged
- Aging
- Alleles
- Apolipoprotein E4
- Cognition
- Cognition Disorders
- Female
- Heterozygote
- Homozygote
- Humans
- Intelligence Tests
- Language Tests
- Male
- Mental Disorders