Article
Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults.
American journal of medical genetics - 4 Dec 2000
Flory J D, Manuck S B, Ferrell R E, Ryan C M, Muldoon M F
Abstract excerpt
The apolipoprotein E genotype (APOE) is an established risk factor for Alzheimer disease, with the age-at-onset occurring earlier in individuals having at least one APOE epsilon 4 allele, relative to the APOE epsilon 3 or APOE epsilon 2 isoforms. Moreover, nondemented older adults with the APOE epsilon 4 allele also show diminished cognitive performance, particularly on tests of learning and memory, and an...
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