Article
Patterns of nucleotide substitutions inferred from the phylogenies of the class I major histocompatibility complex genes.
Journal of molecular evolution - 1 Sept 1992
Imanishi T, Gojobori T
Abstract excerpt
Patterns of nucleotide substitutions in human major histocompatibility complex (MHC) class I genes were estimated by using phylogenetic trees of DNA sequences. The pattern is defined as a set of 12 parameters, each of which represents the relative frequency of substitutions from a particular nucleotide to another. The pattern at the antigen recognition sites (ARS) in functional MHC genes was remarkably different...
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