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Article

Non-random Codon Usage of Synonymous and Non-synonymous Mutations in the Human HLA-A Gene.

Journal of molecular evolution - 1 Apr 2023

Matsushita Tatsuo, Kano-Sueoka Tamiko

Abstract excerpt

The structure and function of human leucocyte antigen (HLA-A) is well known and is an extremely variable protein. From the public HLA-A database, we chose 26 high frequency HLA-A alleles (45% of sequenced alleles). Using five arbitrary references from these alleles, we analyzed synonymous mutations at the third codon position (sSNP3) and non-synonymous mutations (NSM). Both mutation types showed non-random...

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Identifiers

PMID: 36809491
DOI: 10.1007/s00239-023-10093-5

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C3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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