Article
The neutral theory and natural selection in the HLA region.
Frontiers in bioscience : a journal and virtual library - 27 Apr 1998
Satta Y, Li Y J, Takahata N
Abstract excerpt
Based on available DNA sequence data in the HLA region of 4 Mb, we review the degree of polymorphism at 39 loci of which most are involved in the immune system. The extent of nucleotide differences per silent site differs greatly from locus to locus. It is exceptionally high at classical MHC loci...
Topics
- Alleles
- Evolution, Molecular
- Gene Conversion
- Genetic Predisposition to Disease
- HLA Antigens
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Major Histocompatibility Complex
- Models, Genetic
- Polymorphism, Genetic
- Recombination, Genetic
- Selection, Genetic