Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Codon-substitution models to detect adaptive evolution that account for heterogeneous selective pressures among site classes.

Molecular biology and evolution - 1 Jan 2002

Yang Ziheng, Swanson Willie J

Abstract excerpt

The nonsynonymous to synonymous substitution rate ratio (omega = d(N)/d(S)) provides a sensitive measure of selective pressure at the protein level, with omega values <1, =1, and >1 indicating purifying selection, neutral evolution, and diversifying selection, respectively. Maximum likelihood mod...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon
Share to Histocompatibility Antigens Class I
Share to Hydrophobic and Hydrophilic Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Likelihood Functions

Share to Mollusca

Share to Mucoproteins

Share to Solvents

Share to Spermatozoa

Source

Identifiers

PMID: 11752189
DOI: 10.1093/oxfordjournals.molbev.a003981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11752189-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Codon-substitution models to detect adaptive evolution that account for heterogeneous selective pressures among site classes.PMID 11752189Read ↗

Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages.Semantic proximity Read ↗

Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence.Semantic proximity Read ↗

Characterizing molecular adaptation: a hierarchical approach to assess the selective influence of amino acid properties.Semantic proximity Read ↗

Bayes empirical bayes inference of amino acid sites under positive selection.Semantic proximity Read ↗

Integrating sequence variation and protein structure to identify sites under selection.Semantic proximity Read ↗

Diversifying and purifying selection in the peptide binding region of DRB in mammals.Semantic proximity Read ↗

On estimating evolutionary probabilities of population variantsSemantic proximity Read ↗

Detecting natural selection at the molecular level: a reexamination of some "classic" examples of adaptive evolution.Semantic proximity Read ↗

Evolutionary models accounting for layers of selection in protein-coding genes and their impact on the inference of positive selection.Semantic proximity Read ↗

Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes.Semantic proximity Read ↗

Maximum likelihood and Bayesian methods for estimating the distribution of selective effects among classes of mutations using DNA polymorphism data.Semantic proximity Read ↗

Phylogenetics by likelihood: evolutionary modeling as a tool for understanding the genome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.