Article

Natural selection on synonymous genetic variation in the major histocompatibility complex

2026-02-23

Abstract excerpt

Protein coding DNA sequences harbor synonymous nucleotide variation that does not change amino acid sequences but influences phenotypes via multiple effects on the pathway from gene to protein. Synonymous variation has recently been shown to coevolve between viruses and their natural hosts, but its potential role in host immune defenses has not been explored. Here, I present evidence of natural selection on synony...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b95f237-ec50-5469-b0f8-c4671d6f7428
DOI: 10.64898/2026.02.23.707394

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Natural selection on synonymous genetic variation in the major histocompatibility complexDOI 10.64898/2026.02.23.707394Read

Natural selection at major histocompatibility complex loci of vertebrates.Semantic proximity Read

Advances in the Evolutionary Understanding of MHC Polymorphism.Semantic proximity Read

Codon usage and selection on proteins.Semantic proximity Read

The Nature of Selection on the Major Histocompatibility Complex.Semantic proximity Read

High level of functional polymorphism indicates a unique role of natural selection at human immune system loci.Semantic proximity Read

Neutral and selective processes shape MHC gene diversity and expression in stocked brook charr populations (Salvelinus fontinalis).Semantic proximity Read

Non-random Codon Usage of Synonymous and Non-synonymous Mutations in the Human HLA-A Gene.Semantic proximity Read

Estimates of the effect of natural selection on protein-coding content.Semantic proximity Read

Natural selection and the diversification of vertebrate immune effectors.Semantic proximity Read

The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder.Semantic proximity Read

The Evolution of Innate Immune Genes: Purifying and Balancing Selection on β-Defensins in Waterfowl.Semantic proximity Read

Estimating the evolutionary fitness of specific synonymous codon changes.Semantic proximity Read