Article
Progression of multiple sclerosis is associated with exon 1 CTLA-4 gene polymorphism.
Acta neurologica Scandinavica - 1 Jul 2004
Bilińska M, Frydecka I, Noga L, Dobosz T, Zołedziewska M, Suwalska K, Tutak A, Pokryszko-Dragan A
Abstract excerpt
OBJECTIVES: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system which is widely believed to have a T-cell-mediated etiology. The cytotoxic T-lymphocyte antigen-4 (CTLA-4) antigen molecule plays a key role in the downregulation of T-cell responses. To examine the genetic association of the CTLA-4 gene locus with MS, we analyzed an exon 1 (A49G) transition. MATERIAL AND METHODS:...
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