A PD-1 polymorphism is associated with disease progression in multiple sclerosis.

doi:10.1002/ana.20514

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Article

A PD-1 polymorphism is associated with disease progression in multiple sclerosis.

Annals of neurology - 1 Jul 2005

Kroner Antje, Mehling Matthias, Hemmer Bernhard, Rieckmann Peter, Toyka Klaus V, Mäurer Mathias, Wiendl Heinz

Abstract excerpt

T cells are considered to play a pivotal role in orchestrating the self-reactive immune responses in multiple sclerosis (MS). Programmed death 1 (PD-1) is a member of the B7/CD28 superfamily of costimulatory molecules exerting inhibitory functions on T cells. Recently, an intronic 7146G/A polymorphism within the PD-1 gene was described and suggested to be associated with autoimmunity. We investigated whether this...

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PMID: 15912506
DOI: 10.1002/ana.20514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.