Article
No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: a meta-analysis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Mar 2007
Bagos Pantelis G, Karnaouri Anthi C, Nikolopoulos Georgios K, Hamodrakas Stavros J
Abstract excerpt
We conducted a meta-analysis concerning the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with the risk of developing multiple sclerosis (MS). We identified 18 eligible studies summarizing information about 3375 MS cases and 2930 healthy controls. Two polymorphisms were of interest: the exon 1 +49 A/G polymorphism (in 18 studies) and the promoter-318 C/T polymorphism (in...
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