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Article

CTLA4 dimorphisms and the multiple sclerosis phenotype.

Journal of neuroimmunology - 1 Oct 2002

Masterman Thomas, Ligers Arturs, Zhang Zhiping, Hellgren Dennis, Salter Hugh, Anvret Maria, Hillert Jan

Abstract excerpt

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), expressed on activated T cells, binds to B7 molecules on antigen-presenting cells. Signaling via CTLA-4 results in downregulation of ongoing T-cell clonal expansion. A single-nucleotide polymorphism (SNP) in exon 1 of CTLA4 is associated with susceptibility to several autoimmune diseases, including multiple sclerosis (MS). In this two-stage study, we...

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Source

Identifiers

PMID: 12458054
DOI: 10.1016/s0165-5728(02)00274-6

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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