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Article

Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties.

The Journal of biological chemistry - 23 Mar 2007

Bae Jong-Sup, Yang Likui, Manithody Chandrashekhara, Rezaie Alireza R

Abstract excerpt

In addition to an anticoagulant activity, activated protein C (APC) also exhibits anti-inflammatory and cytoprotective properties. These properties may contribute to the beneficial effect of APC in treating severe sepsis patients. A higher incidence of bleeding because of its anticoagulant function has been found to be a major drawback of APC as an effective anti-inflammatory drug. In this study, we have prepared...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17255099
DOI: 10.1074/jbc.M610547200

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties.PMID 17255099Read ↗

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Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.Semantic proximity Read ↗

The functional significance of the autolysis loop in protein C and activated protein C.Semantic proximity Read ↗

Activated protein C: biased for translationSemantic proximity Read ↗

Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va.Semantic proximity Read ↗

Asn384Ser Mutation in Protein C is Associated with Multiple-Site Thrombosis in a Young Heterozygous Male.Semantic proximity Read ↗

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