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Article

Engineering the proteolytic specificity of activated protein C improves its pharmacological properties.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2003

Berg David T, Gerlitz Bruce, Shang Jing, Smith Tommy, Santa Paula, Richardson Mark A, Kurz Ken D, Grinnell Brian W, Mace Ken, Jones Bryan E

Abstract excerpt

Human activated protein C (APC) is an antithrombotic, antiinflammatory serine protease that plays a central role in vascular homeostasis, and activated recombinant protein C, drotrecogin alfa (activated), has been shown to reduce mortality in patients with severe sepsis. Similar to other serine proteases, functional APC levels are regulated by the serine protease inhibitor family of proteins including...

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Identifiers

PMID: 12671072
DOI: 10.1073/pnas.0736918100
PMCID: PMC153571

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Engineering the proteolytic specificity of activated protein C improves its pharmacological properties.PMID 12671072Read ↗

Activated protein C: biased for translationSemantic proximity Read ↗

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Divergent modulation of activated protein C pleiotropic functions by antibodies that differ by a single amino acid.Semantic proximity Read ↗

The structure-function relationship of activated protein C. Lessons from natural and engineered mutations.Semantic proximity Read ↗

Basic residues in the 37-loop of activated protein C modulate inhibition by protein C inhibitor but not by alpha(1)-antitrypsin.Semantic proximity Read ↗

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity.Semantic proximity Read ↗

Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.Semantic proximity Read ↗

Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties.Semantic proximity Read ↗

Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury.Semantic proximity Read ↗

Expanding the clinical utility of therapeutic proteins: activated protein C variants with improved pharmacological properties.Semantic proximity Read ↗

Massively parallel, computationally-guided design of a pro-enzymeSemantic proximity Read ↗

Evolution of serpin specificity: cooperative interactions in the reactive-site loop sequence of antithrombin specifically restrict the inhibition of activated protein C.Semantic proximity Read ↗

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