Article
The structure-function relationship of activated protein C. Lessons from natural and engineered mutations.
Thrombosis and haemostasis - 1 Dec 2011
Wildhagen Karin C A A, Lutgens Esther, Loubele Sarah T G B, ten Cate Hugo, Nicolaes Gerry A F
Abstract excerpt
Protein C is the central enzyme of the natural anticoagulant pathway and its activated form APC (activated protein C) is able to proteolyse non-active as well as active coagulation factors V and VIII. Proteolysis renders these cofactors inactive, resulting in an attenuation of thrombin formation and overall down-regulation of coagulation. Presences of the APC cofactor, protein S, thrombomodulin, endothelial...
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