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Article

Divergent modulation of activated protein C pleiotropic functions by antibodies that differ by a single amino acid.

Blood advances - 14 Jan 2025

Sim Derek S, Shukla Meenal, Mallari Cornell R, Fernández José A, Xu Xiao, Schneider Doug, Bauzon Maxine, Hermiston Terry W, Mosnier Laurent O

Abstract excerpt

ABSTRACT: Activated protein C (APC) is a pleiotropic plasma protease with diverse functions derived from its anticoagulant, anti-inflammatory, and cytoprotective activities. The selective uncoupling and/or modulation of these APC activities by antibodies may have therapeutic benefit in diseases such as traumatic bleeding, hemophilia, sepsis, and ischemia. TPP-26870 is an antibody that targets a nonactive site of...

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PMID: 39471469
DOI: 10.1182/bloodadvances.2024013584

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