Mitochondrial respiration and reactive oxygen species in mitochondrial aging mutants.

Abstract excerpt

A powerful approach to understanding a complex process such as aging is to study the process in model organisms that are amenable to genetic dissection. Several mutant strains in different organisms have been identified that affect lifespan; data from these organisms indicate that mitochondrial function is a major factor affecting lifespan. Mutations which affect some aspect of mitochondrial function and affect...

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