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Article

A mutation in mitochondrial complex I increases ethanol sensitivity in Caenorhabditis elegans.

Alcoholism, clinical and experimental research - 1 Apr 2003

Kayser Ernst-Bernhard, Hoppel Charles L, Morgan Phil G, Sedensky Margaret M

Abstract excerpt

BACKGROUND: The gene gas-1 encodes the 49-kDa subunit of complex I of the mitochondrial electron transport chain in Caenorhabditis elegans. A mutation in gas-1 profoundly increases sensitivity to ethanol and decreases complex I-dependent metabolism in mitochondria. METHODS: Mitochondria were isolated from wild-type and gas-1 strains of C. elegans. The effects of ethanol on complex I-, II-, and III-dependent...

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PMID: 12711920
DOI: 10.1097/01.ALC.0000060524.62805.D2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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