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Article

A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans.

PLoS genetics - 1 Apr 2009

Cristina David, Cary Michael, Lunceford Adam, Clarke Catherine, Kenyon Cynthia

Abstract excerpt

When mitochondrial respiration or ubiquinone production is inhibited in Caenorhabditis elegans, behavioral rates are slowed and lifespan is extended. Here, we show that these perturbations increase the expression of cell-protective and metabolic genes and the abundance of mitochondrial DNA. This response is similar to the response triggered by inhibiting respiration in yeast and mammalian cells, termed the...

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Identifiers

PMID: 19360127
DOI: 10.1371/journal.pgen.1000450
PMCID: PMC2660839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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