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Article

Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans.

Current biology : CB - 22 Aug 2006

Falk Marni J, Kayser Ernst-Bernhard, Morgan Philip G, Sedensky Margaret M

Abstract excerpt

Despite the widespread clinical use of volatile anesthetics, their mechanisms of action remain unknown [1-6]. An unbiased genetic screen in the nematode C. elegans for animals with altered volatile anesthetic sensitivity identified a mutant in a nuclear-encoded subunit of mitochondrial complex I [7,8]. This raised the question of whether mitochondrial dysfunction might be the primary mechanism by which volatile...

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Identifiers

PMID: 16920626
DOI: 10.1016/j.cub.2006.06.072
PMCID: PMC3641903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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