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Article

IL4-589C/T polymorphism and IgE levels in severe malaria.

Acta tropica - 1 Apr 2004

Verra Federica, Luoni Gaia, Calissano Carlo, Troye-Blomberg Marita, Perlmann Peter, Perlmann Hedvig, Arcà Bruno, Sirima Bienvenu Sodiomon, Konaté Amadou, Coluzzi Mario, Kwiatkowski Dominic, Modiano David

Abstract excerpt

Previous studies identified an allelic variant of the IL4 promoter region (IL4-589T) that appears to enhance the transcriptional activity of IL4, and is associated with increased IgE levels. Total serum IgE levels are elevated in malaria endemic regions, and higher in children with severe malaria. Here, we investigated the relationship of the IL4-589C/T polymorphism with severity of the disease in a case-control...

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Identifiers

PMID: 15177147
DOI: 10.1016/j.actatropica.2003.11.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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