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Article

Cytokine gene haplotypes with a potential effect on susceptibility to malaria in sympatric ethnic groups in Mali.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2011

Israelsson Elisabeth, Maiga Bakary, Kearsley Susannah, Dolo Amagana, Homann Manijeh Vafa, Doumbo Ogobara K, Troye-Blomberg Marita, Tornvall Per, Berzins Klavs

Abstract excerpt

Cytokines are important players in the immune responses, and an unbalance in pro- and anti-inflammatory cytokine responses may affect parasitemia and pathology in a Plasmodium falciparum infection. Polymorphisms in cytokine genes may affect not only the levels of the protein, but many down-stream functions, such as production of C-reactive protein and immunoglobulin isotype switching. Susceptibility to malaria...

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PMID: 21708291
DOI: 10.1016/j.meegid.2011.05.021

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TNF

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