Article
Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children.
Clinical and experimental immunology - 1 Oct 2004
Gyan B A, Goka B, Cvetkovic J T, Kurtzhals J L, Adabayeri V, Perlmann H, Lefvert A-K, Akanmori B D, Troye-Blomberg M
Abstract excerpt
Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and - 590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL-4 intron-3 B1B1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.