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Article

Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jun 2004

Song Inseon, Kim Daesoo, Choi Soonwook, Sun Minjeong, Kim Yeongin, Shin Hee-Sup

Abstract excerpt

Alterations in thalamic T-type Ca2+ channels are thought to contribute to the pathogenesis of absence seizures. Here, we found that mice with a null mutation for the pore-forming alpha1A subunits of P/Q-type channels (alpha1A-/- mice) were prone to absence seizures characterized by typical spike-and-wave discharges (SWDs) and behavioral arrests. Isolated thalamocortical relay (TC) neurons from these mice showed...

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Identifiers

PMID: 15175395
DOI: 10.1523/JNEUROSCI.5546-03.2004
PMCID: PMC6729205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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