Article
Transgenic mice over-expressing GABA(B)R1a receptors acquire an atypical absence epilepsy-like phenotype.
Neurobiology of disease - 1 May 2007
Wu Ying, Chan Katherine F Y, Eubanks James H, Guin Ting Wong C, Cortez Miguel A, Shen Liqing, Che Liu Chun, Perez Velazquez Jose, Tian Wang Yu, Jia Zhengping, Carter Snead O
Abstract excerpt
In this study, we tested whether over-expressing the GABA(B) receptor R1a subtype in transgenic mouse forebrain neurons would be sufficient to induce spontaneous absence seizures. As hypothesized, these transgenic mice develop spontaneous, recurrent, bilaterally synchronous, 3-6 Hz slow spike and wave discharges between 2 and 4 months of age. These discharges are blocked by ethosuximide and exacerbated by...
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