Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic studies on the role of T-type Ca2+ channels in sleep and absence epilepsy.

CNS & neurological disorders drug targets - 1 Dec 2006

Shin Hee-Sup, Lee Jungryun, Song Inseon

Abstract excerpt

Thalamocortical neurons in mammals fire action potentials in two different modes, burst or tonic, depending on the cellular state. The burst firing is driven by the low threshold Ca2+ spike that is generated by Ca2+ influx through T-type Ca2+ channels, and has long been implicated in the pathogenesis of absence epilepsy and the regulation of sleep rhythms. The recent availability of the knock-out mice for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channels, T-Type
Share to Epilepsy, Absence
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Source

Identifiers

PMID: 17168747
DOI: 10.2174/187152706779025553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic studies on the role of T-type Ca2+ channels in sleep and absence epilepsy.PMID 17168747Read ↗

T-type Ca2+ channels and absence epilepsy.Semantic proximity Read ↗

T-type Ca2+ channels in absence epilepsy.Semantic proximity Read ↗

Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice.Semantic proximity Read ↗

Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons.Semantic proximity Read ↗

The role of calcium channel mutations in human epilepsy.Semantic proximity Read ↗

Genes and molecular mechanisms involved in the epileptogenesis of idiopathic absence epilepsies.Semantic proximity Read ↗

The role of T-type calcium channels in epilepsy and pain.Semantic proximity Read ↗

Absence-like seizures and their pharmacological profile in tottering-6j mice.Semantic proximity Read ↗

Lack of delta waves and sleep disturbances during non-rapid eye movement sleep in mice lacking alpha1G-subunit of T-type calcium channels.Semantic proximity Read ↗

Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel.Semantic proximity Read ↗

Tonic Inhibition is Abolished in GABA <sub>A</sub> Receptor γ2R43Q Knock-in Mice with Absence Epilepsy and Febrile SeizuresSemantic proximity Read ↗

Single gene defects in mice: the role of voltage-dependent calcium channels in absence models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.