Article
Differential expression of T-type calcium channels in P/Q-type calcium channel mutant mice with ataxia and absence epilepsy.
Journal of neurobiology - 15 Feb 2005
Nahm Sang-Soep, Jung Ki-Yoon, Enger Melanie Krause, Griffith William H, Abbott Louise C
Abstract excerpt
Mutations in P/Q-type calcium channels generate common phenotypes in mice and humans, which are characterized by ataxia, paroxysmal dyskinesia, and absence seizures. Subsequent functional changes of T-type calcium channels in thalamus are observed in P/Q-type calcium channel mutant mice and these changes play important roles in generation of absence seizures. However, the changes in T-type calcium channel...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
