Effects of the T-type calcium channel CaV3.2 R1584P mutation on absence seizure susceptibility in GAERS and NEC congenic rats models.

doi:10.1016/j.nbd.2023.106217

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Article

Effects of the T-type calcium channel CaV3.2 R1584P mutation on absence seizure susceptibility in GAERS and NEC congenic rats models.

Neurobiology of disease - 1 Aug 2023

Casillas-Espinosa Pablo M, Lin Runxuan, Li Rui, Nandakumar Nanditha M, Dawson Georgia, Braine Emma L, Martin Benoît, Powell Kim L, O'Brien Terence J

Abstract excerpt

RATIONALE: Low-voltage-activated or T-type Ca2+ channels play a key role in the generation of seizures in absence epilepsy. We have described a homozygous, gain of function substitution mutation (R1584P) in the CaV3.2 T-type Ca2+ channel gene (Cacna1h) in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS). The non-epileptic control (NEC) rats, derived from the same original Wistar strains as GAERS but...

Topics

Animals
Rats
Calcium Channels, T-Type
Disease Models, Animal
Electroencephalography
Epilepsy, Absence
Mutation
Rats, Wistar
Seizures

Source

Open in PubMed

Identifiers

PMID: 37391087
DOI: 10.1016/j.nbd.2023.106217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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