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Article

Single gene defects in mice: the role of voltage-dependent calcium channels in absence models.

Epilepsy research - 1 Sept 1999

Burgess D L, Noebels J L

Abstract excerpt

Nineteen genes encoding alpha1, beta, gamma, or alpha2delta voltage-dependent calcium channel subunits have been identified to date. Recent studies have found that three of these genes are mutated in mice with generalised cortical spike-wave discharges (models of human absence epilepsy), emphasising the importance of calcium channels in regulating the expression of this inherited seizure phenotype. The tottering...

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PMID: 10515159
DOI: 10.1016/s0920-1211(99)00045-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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