Article
T-type Ca2+ channels and absence epilepsy.
Cell calcium - 1 Aug 2006
Shin Hee-Sup
Abstract excerpt
Burst firing of the thalamic neurons is driven by the low threshold Ca2+ spike generated by Ca2+ influx through T-type Ca2+ channels when these channels are activated by membrane hyperpolarization due to inhibitory inputs. The major inhibitory inputs to the thalamocortical (TC) neurons are from the GABAergic neurons in the thalamic reticular nucleus. Thalamic burst firings have long been implicated in the...
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