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Article

Homotypic signalling regulates Gata1 activity in the erythroblastic island.

Development (Cambridge, England) - 1 Jul 2004

Gutiérrez Laura, Lindeboom Fokke, Langeveld An, Grosveld Frank, Philipsen Sjaak, Whyatt David

Abstract excerpt

Gata1 is a transcription factor essential for erythropoiesis. Erythroid cells lacking Gata1 undergo apoptosis, while overexpression of Gata1 results in a block in erythroid differentiation. However, erythroid cells overexpressing Gata1 differentiate normally in vivo when in the presence of wild-type cells. We have proposed a model, whereby a signal generated by wild-type cells (red cell differentiation signal;...

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Source

Identifiers

PMID: 15175249
DOI: 10.1242/dev.01198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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