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Article

A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 1997

McDevitt M A, Shivdasani R A, Fujiwara Y, Yang H, Orkin S H

Abstract excerpt

The hematopoietic-restricted transcription factor GATA-1 is required for both mammalian erythroid cell and megakaryocyte differentiation. To define the mechanisms governing its transcriptional regulation, we replaced upstream sequences including a DNase I hypersensitive (HS) region with a neomycin-resistance cassette by homologous recombination in mouse embryonic stem cells and generated mice either harboring...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9192642
DOI: 10.1073/pnas.94.13.6781
PMCID: PMC21235

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Source receipt: pubmed, retrieved 7 Sept 2026.

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