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Article

Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors.

The Journal of biological chemistry - 10 Jun 2005

Pan Xiaoqing, Ohneda Osamu, Ohneda Kinuko, Lindeboom Fokke, Iwata Fumiko, Shimizu Ritsuko, Nagano Masumi, Suwabe Naruyoshi, Philipsen Sjaak, Lim Kim-Chew, Engel James D, Yamamoto Masayuki

Abstract excerpt

Transcription factor GATA-1 plays an important role in gene regulation during the development of erythroid cells. Several reports suggest that GATA-1 plays multiple roles in survival, proliferation, and differentiation of erythroid cells. However, little is known about the relationship between the level of GATA-1 expression and its nature of multifunction to affect erythroid cell fate. To address this issue, we...

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Identifiers

PMID: 15817467
DOI: 10.1074/jbc.M500081200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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