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Article

Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.

Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 1996

Fujiwara Y, Browne C P, Cunniff K, Goff S C, Orkin S H

Abstract excerpt

The X chromosome-linked transcription factor GATA-1 is expressed specifically in erythroid, mast, megakaryocyte, and eosinophil lineages, as well as in hematopoietic progenitors. Prior studies revealed that gene-disrupted GATA-1- embryonic stem cells give rise to adult (or definitive) erythroid precursors arrested at the proerythroblast stage in vitro and fail to contribute to adult red blood cells in chimeric...

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Identifiers

PMID: 8901585
DOI: 10.1073/pnas.93.22.12355
PMCID: PMC37995

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Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.PMID 8901585Read ↗

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Development of hematopoietic cells lacking transcription factor GATA-1Semantic proximity Read ↗

Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1.Semantic proximity Read ↗

Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells.Semantic proximity Read ↗

GATA-1 regulates growth and differentiation of definitive erythroid lineage cells during in vitro ES cell differentiation.Semantic proximity Read ↗

Transcription factor GATA-1 and erythroid development.Semantic proximity Read ↗

Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In VivoSemantic proximity Read ↗

Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors.Semantic proximity Read ↗

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Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesisSemantic proximity Read ↗

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