Article
Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.
Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 1996
Fujiwara Y, Browne C P, Cunniff K, Goff S C, Orkin S H
Abstract excerpt
The X chromosome-linked transcription factor GATA-1 is expressed specifically in erythroid, mast, megakaryocyte, and eosinophil lineages, as well as in hematopoietic progenitors. Prior studies revealed that gene-disrupted GATA-1- embryonic stem cells give rise to adult (or definitive) erythroid precursors arrested at the proerythroblast stage in vitro and fail to contribute to adult red blood cells in chimeric...
Topics
- Alleles
- Animals
- DNA-Binding Proteins
- Erythroid-Specific DNA-Binding Factors
- Erythropoiesis
- Female
- GATA1 Transcription Factor
- GATA2 Transcription Factor
- Gene Expression Regulation, Developmental
- Globins
- Male
- Mice
- Nuclear Proteins