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Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells

10 May 2015

Abstract excerpt

Transfusion of donor-derived platelets is commonly used for thrombocytopenia, which results from a variety of clinical conditions and relies on a constant donor supply due to the limited shelf life of these cells. Embryonic stem (ES) and induced pluripotent stem (iPS) cells represent a potential source of megakaryocytes and platelets for transfusion therapies; however, the majority of current ES/iPS cell...

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PMID: 25961454
DOI: 10.1172/jci77670

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