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Article

Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion

1 Jun 2016

Abstract excerpt

Erythroid cell commitment and differentiation proceed through activation of a lineage-restricted transcriptional network orchestrated by a group of well characterized genes. However, the minimal set of factors necessary for instructing red blood cell (RBC) development remains undefined. We employed a screen for transcription factors allowing direct lineage reprograming from fibroblasts to induced erythroid...

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PMID: 27264182
DOI: 10.1016/j.celrep.2016.05.027

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