Article
Role of GATA-1 in proliferation and differentiation of definitive erythroid and megakaryocytic cells in vivo.
Blood - 15 Jul 1998
Takahashi S, Komeno T, Suwabe N, Yoh K, Nakajima O, Nishimura S, Kuroha T, Nagasawa T, Yamamoto M
Abstract excerpt
To elucidate the contributions of GATA-1 to definitive hematopoiesis in vivo, we have examined adult mice that were rendered genetically defective in GATA-1 synthesis (Takahashi et al, J Biol Chem 272:12611, 1997). Because the GATA-1 gene is located on the X chromosome, which is randomly inactivated in every cell, heterozygous females can bear either an active wild-type or mutant (referred to as GATA-1.05) GATA-1...
Topics
- Animals
- Cell Differentiation
- DNA-Binding Proteins
- Erythroblasts
- Erythroid-Specific DNA-Binding Factors
- Female
- GATA1 Transcription Factor
- Hematopoiesis
- Hematopoietic Stem Cells
- Humans
- Megakaryocytes
- Mice
- Mutation
- Spleen
- Transcription Factors