Article
Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells.
Molecular cell - 4 Jun 2004
Guirouilh-Barbat Josée, Huck Sylvie, Bertrand Pascale, Pirzio Livia, Desmaze Chantal, Sabatier Laure, Lopez Bernard S
Abstract excerpt
Using a substrate measuring deletion or inversion of an I-SceI-excised fragment and both accurate and inaccurate rejoining, we determined the impact of non-homologous end-joining (NHEJ) on mammalian chromosome rearrangements. Deletion is 2- to 8-fold more efficient than inversion, independent of the DNA ends structure. KU80 controls accurate rejoining, whereas in absence of KU mutagenic rejoining, particularly...
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