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Article

Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells.

PLoS genetics - 26 Feb 2010

Fattah Farjana, Lee Eu Han, Weisensel Natalie, Wang Yongbao, Lichter Natalie, Hendrickson Eric A

Abstract excerpt

The repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genomic integrity and viability for all organisms. Mammals have evolved at least two genetically discrete ways to mediate DNA DSB repair: homologous recombination (HR) and non-homologous end joining (NHEJ). In mammalian cells, most DSBs are preferentially repaired by NHEJ. Recent work has demonstrated that NHEJ consists of at least...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20195511
DOI: 10.1371/journal.pgen.1000855
PMCID: PMC2829059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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